MACS Treatment: Advanced Sperm Selection for IVF Success

Magnetic Activated Cell Sorting (MACS) is an advanced, non-invasive sperm selection technique that helps identify and isolate live, non-apoptotic sperm cells—those with intact DNA and no signs of damage or programmed cell death (apoptosis). This process significantly enhances sperm quality by filtering out damaged or dying sperm cells, which are known to negatively impact fertilization and embryo development.

In assisted reproductive treatments, semen quality plays a critical role in achieving a successful pregnancy. One key factor affecting semen quality is the presence of apoptotic sperm. These sperm cells exhibit markers on their membranes that can be detected and removed using the MACS procedure, thereby improving overall semen quality. This technique is especially beneficial for men with varicocele, a condition associated with increased sperm DNA fragmentation and abnormal semen parameters.

MACS can be beneficial for a wide range of patients undergoing assisted reproduction, particularly in the following scenarios:

The MACS procedure involves passing a prepared semen sample through a magnetic column. Sperm cells that show signs of apoptosis are tagged with magnetic microbeads and get trapped in the column, while healthy, motile, and DNA-intact sperm cells flow through and are collected for use.

This enriched sperm population is then typically used for fertilization through ICSI (Intracytoplasmic Sperm Injection)—a highly precise IVF technique where a single healthy sperm is directly injected into an egg. Since ICSI does not rely on the sperm's ability to swim or penetrate the egg, it is ideal for use with sperm selected via MACS.

MACS is especially useful for patients with a DNA Fragmentation Index (DFI) higher than 25%, which indicates poor sperm DNA integrity. By reducing DNA fragmentation, MACS helps improve fertilization outcomes, enhance embryo quality, and increase pregnancy rates—especially in cases with a history of failed IVF cycles or poor implantation.

At GarbhaGudi IVF Centre, we combine cutting-edge technology with compassionate care to offer advanced solutions like MACS to couples facing complex fertility challenges. With a team of highly experienced fertility specialists and state-of-the-art facilities, GarbhaGudi has established itself as a leading IVF center in Bangalore. We specialize in offering customized fertility treatments that yield high success rates, helping couples realize their dream of parenthood.