Sequential Embryo Transfer (SET) – A Revolutionary Step Towards Parenthood
What is Sequential Embryo Transfer (SET)?
Sequential Embryo Transfer (SET) involves transferring two sets of embryos at different developmental stages—typically on Day 3 (cleavage stage) and Day 5 (blastocyst stage)—within the same IVF cycle.
This technique is especially beneficial for patients with a good number of viable oocytes, as it combines the benefits of both early and advanced-stage embryo transfers. SET helps improve implantation and pregnancy rates, while also reducing the risk of cycle cancellation, which can occur during blastocyst-only transfers. It is particularly helpful for patients who have experienced repeated IVF failures despite having good-quality embryos.
When is SET Recommended?
SET is typically advised for couples who have undergone multiple unsuccessful IVF attempts. These patients often present with high-quality embryos yet still fail to achieve pregnancy. In such cases, SET offers renewed hope. Research indicates that while conventional IVF yields an average pregnancy rate of around 20%, SET has shown success rates exceeding x50% in some patient groups.
Why Consider SET?
SET is based on two key principles:
Enhanced Embryo Selection: Cultivating embryos up to the blastocyst stage allows for more informed selection, reducing the chance of transferring embryos that may not survive or implant.
Improved Uterine Synchrony: Transferring embryos on both Day 3 and Day 5 enhances synchronization with the endometrial lining, optimizing conditions for implantation.
Additionally, the initial Day 3 transfer may stimulate the endometrium to become more receptive, creating a more favorable environment for the subsequent Day 5 blastocyst transfer.
How Embryos and the Uterus Communicate
There’s growing evidence that embryos release signaling molecules like cytokines, which help prepare the uterine lining for implantation. By introducing embryos on Day 3, the uterine environment may be “primed” to better accept the second set of embryos transferred on Day 5. This biological interaction may play a vital role in improving implantation outcomes.
Key Benefits of SET
Optimized Embryo Selection: Transferring only the healthiest embryos reduces the risk of multiple pregnancies while increasing implantation efficiency.
Higher Pregnancy Rates: The dual-stage transfer boosts the likelihood of successful implantation.
Reduced Need for Embryo Freezing: By using more embryos during the fresh cycle, there’s less reliance on freezing potentially non-viable ones.
Option for Future Transfers: Any unused blastocysts can still be cryopreserved and used in future cycles if needed.
SET at GarbhaGudi IVF Centre
At GarbhaGudi IVF Centre, we have developed expertise in Sequential Embryo Transfer and have helped many couples achieve successful pregnancies after repeated failures elsewhere. Our specialized protocols, personalized care, and advanced laboratory techniques make us a preferred destination for patients across India seeking second opinions and better outcomes.
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